Xiao-Jun Du and Anthony M. Dart

in The Pharmacology of Vascular Smooth Muscle

Published in print February 1996 | ISBN: 9780192623874
Published online March 2012 | e-ISBN: 9780191724671 | DOI:

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It has now become clear that the physiological and pharmacological behaviour of vascular smooth muscle, particularly in the coronary circulation, is abnormal throughout the evolution of atherosclerosis. This chapter reviews these pathophysiological alterations and the consequently modified (or even paradoxical) pharmacological characteristics of coronary vasculature. Clinical and experimental studies on atherosclerotic coronary arteries have demonstrated an abnormal vasoconstriction in response to various pharmacological agents which induce vasodilation in non-atherosclerotic arteries. Intracoronary injection of ACh or 5-HT in man induces a dose-dependent vasoconstrictor response in segments with atherosclerotic damage but the vasodilator response to nitroglycerin is intact.

Keywords: coronary circulation; coronary vasculature; coronary arteries; vasodilation; vasoconstriction; acetylcholine

Chapter.  5324 words.  Illustrated.

Subjects: Neuroscience

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