Chapter

Vessel wall injury and growth: pharmacological considerations in atherosclerosis and collateral artery function

Norman K. Hollenberg

in The Pharmacology of Vascular Smooth Muscle

Published in print February 1996 | ISBN: 9780192623874
Published online March 2012 | e-ISBN: 9780191724671 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780192623874.003.0015
Vessel wall injury and growth: pharmacological considerations in atherosclerosis and collateral artery function

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Arteries relax in response to some vasodilators only if the endothelium is present. The obligatory role for vasodilatation of a diffusible factor from endothelium termed ‘EDRF’ for endothelial-dependent relaxing factor, now identified as nitric oxide or a related nitroso-thiol has been demonstrated for many agents, including acetylcholine, bradykinin, substance P, ATP, other adenine nucleotides — and especially important for this chapter — the vasodilator action of 5-HT. Other vasodilator agents, however, such as nitrates, papaverine, isoproterenol, and prostaglandins, do not require endothelium. This chapter focuses on pharmacological considerations in atherosclerosis and in the collateral arteries that grow in response to the vascular occlusion that so often occurs with atherosclerosis.

Keywords: EDRF; nitric oxide; collateral arteries; atherosclerosis; vascular occlusion

Chapter.  7650 words. 

Subjects: Neuroscience

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