The cerebral microvascular endothelium in ischaemia

A. Lorris Betz and Fausto Iannotti

in The Pharmacology of Vascular Smooth Muscle

Published in print February 1996 | ISBN: 9780192623874
Published online March 2012 | e-ISBN: 9780191724671 | DOI:
The cerebral microvascular endothelium in ischaemia

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The brain microvasculature is composed of smooth muscle cells, endothelial cells, and pericytes and each of these is subject to injury in ischaemia. The function of the pericyte and its response to disease is largely unknown. This chapter focuses on the microvascular endothelial cell in brain, how its function is regulated, and the mechanisms by which its function is altered in ischaemia. Although to date there are few examples of pharmacological agents which have been shown to attenuate ischaemic damage to the cerebral microvasculature, it is believed that, with an understanding of the mechanisms which produce injury to endothelial cells, it should be possible to develop effective therapeutic interventions.

Keywords: cerebral microvascular endothelium; ischaemia; microvascular endothelial cells; brain; pericytes; smooth muscle cells

Chapter.  5313 words.  Illustrated.

Subjects: Neuroscience

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