. Pulmonary hypertension

George Cremona and Tim Higenbottam

in The Pharmacology of Vascular Smooth Muscle

Published in print February 1996 | ISBN: 9780192623874
Published online March 2012 | e-ISBN: 9780191724671 | DOI:
. Pulmonary hypertension

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Over the last fifty years information has been steadily accumulating demonstrating the astonishingly complex systems for active regulation of blood flow in the lung and refuting the earlier notions regarding the pulmonary circulation simply as a passive conduit for the flow of blood to and from the alveoli. The emerging evidence of the endocrine and paracrine role of the endothelium has had a major impact on the understanding of local mechanisms of vascular control in the systemic circulation where the importance of the regulation of vascular tone has long been recognized. This chapter aims to outline the unique characteristics of the pulmonary circulation and to present some of the information regarding the role of the endothelium in regulating pulmonary vascular tone and how this is altered in pulmonary hypertensive states.

Keywords: pulmonary circulation; blood flow; pulmonary hypertension; alveoli; endothelium; vascular tone

Chapter.  11710 words.  Illustrated.

Subjects: Neuroscience

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