Early development of the telencephalon

David J. Price and David J. Willshaw

in Mechanisms of Cortical Development

Published in print April 2000 | ISBN: 9780192624277
Published online January 2010 | e-ISBN: 9780191723735 | DOI:

Series: Monographs of the Physiological Society

Early development of the telencephalon

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Brain develops from embryonic ectoderm, one of the three germ layers of the embryo, the other two being endoderm and mesoderm. Much of our knowledge of early embryogenesis is derived from studies of amphibia, whose large eggs and embryos are relatively easy to observe and manipulate, and many of the main features are similar in mammals. This chapter deals with mammalian development, in particular the embryogenesis of the mouse, and the early development of the telencephalon. Mammalian embryogenesis and the emergence of the forebrain are discussed, along with the fate of the anterior neural plate, the anatomy of the developing telencephalon, the specification of telencephalic regional identity, the anatomy of the developing neocortex, cell proliferation and cell migration in neocortical development, the switch from neurogenesis to gliogenesis, cell lineage, and how the fates of cortical cells are determined.

Keywords: telencephalon; embryogenesis; mammals; mouse; forebrain; anterior neural plate; neocortex; cell proliferation; cell migration; cortical cells

Chapter.  15806 words.  Illustrated.

Subjects: Neuroscience

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