Chapter

Molecular regulation of early forebrain and cortical development

David J. Price and David J. Willshaw

in Mechanisms of Cortical Development

Published in print April 2000 | ISBN: 9780192624277
Published online January 2010 | e-ISBN: 9780191723735 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780192624277.003.0003

Series: Monographs of the Physiological Society

Molecular regulation of early forebrain and cortical development

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Over the past few decades, higher mammals with larger and more advanced brains, such as cats and primates, have been studied by many scientists interested in the development of the cerebral cortex. Prominent examples are Nobel laureates David Hubel and Torsten Wiesel, who worked on cortical development and the effects of visual deprivation. Much of their work (as well as that of numerous researchers stimulated by their studies) was carried out on cats. One reason for this tendency may be a desire to understand the development of the human brain and its perceptual and cognitive functions. This chapter discusses the molecular recognition of early forebrain and cortical development, experiments with mouse developmental genetics, methods for manipulating the mouse genome, genes that regulate development in Drosophila, types of molecule that regulate forebrain development, transcription factors, extracellular signalling and cell adhesion, inductive interactions in forebrain development, generation of regional diversity in the forebrain, formal models of regional specification, regulation of size differences between major forebrain structures, growth factors, molecular control of cell migration and cell differentiation, and types of cortical cells.

Keywords: forebrain; cortical development; mammals; developmental genetics; mouse; genome; transcription factors; formal models; cortical cells; cerebral cortex

Chapter.  15824 words.  Illustrated.

Subjects: Neuroscience

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