Chapter

Map formation

David J. Price and David J. Willshaw

in Mechanisms of Cortical Development

Published in print April 2000 | ISBN: 9780192624277
Published online January 2010 | e-ISBN: 9780191723735 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780192624277.003.0005

Series: Monographs of the Physiological Society

Map formation

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All neurons in the mature nervous system are mapped onto the neurons to which they connect; and therefore, understanding how neural mappings are achieved could be considered synonymous with understanding how every aspect of the connectivity of the nervous system is established. This chapter discusses the development of topographically ordered maps of connections, hypotheses for map formation, the development of topographic maps in non-cortical systems, rhe role of fibre ordering in map-making, cytodifferentiation hypothesis, neighbour matching hypothesis, induction of specificity hypothesis, timing hypothesis, development of topographic maps in cortical systems, thalamo-cortical projection and whether the cortical map is specified prior to innervation, mapping to specific cortical areas, the development of callosal and ipsilateral corticocortical projections, the development of feature maps in the visual system, development of geniculate projections to the visual cortex, the effects of neural activity (especially with respect to functional deprivation), models for map-making, models for the development of topography, models based on chemoaffinity, and models for the development of cortical feature maps.

Keywords: nervous system; neurons; topographic maps; cytodifferentiation; neighbour matching hypothesis; visual system; cortical areas; visual cortex; chemoaffinity

Chapter.  25558 words.  Illustrated.

Subjects: Neuroscience

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