Chapter

Mechanisms controlling the development of cortical connections at the target

David J. Price and David J. Willshaw

in Mechanisms of Cortical Development

Published in print April 2000 | ISBN: 9780192624277
Published online January 2010 | e-ISBN: 9780191723735 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780192624277.003.0006

Series: Monographs of the Physiological Society

Mechanisms controlling the development of cortical connections at the target

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The preceding chapters have described how the embryonic anatomy of the early forebrain is established under the control of regulatory genes and extracellular signalling molecules. This chapter describes the mechanisms controlling the development of cortical connections at the cellular and subcellular levels. Among the key influences discussed are the role of neurotrophic factors and activity-dependent events. The mechanisms of cell death are explained along with the role of growth factors such as neurotrophins, cytokines, regulation of cell death in the developing cerebral cortex and its connections, modification of cortical connections and circuits by activity, long-term potentiation and long-term depression, neonatal cortical plasticity, models for activity-dependent synaptic modification, molecular links between activity and synaptic change, models of competition, and the regulation of the dendritic growth of cortical neurons.

Keywords: cortical connections; neurotrophic factors; growth factors; neurotrophins; cytokines; cerebral cortex; cell death; cortical neurons; cortical development

Chapter.  14287 words.  Illustrated.

Subjects: Neuroscience

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