Chapter

The NMDA receptor concept: origins and development

J. C. WATKINS

in The NMDA Receptor

Second edition

Published in print February 1995 | ISBN: 9780192625021
Published online March 2012 | e-ISBN: 9780191724701 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780192625021.003.0001
The NMDA receptor concept: origins and development

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The progress of research in the excitatory amino acid (EAA) field over the last forty years is well documented. The field had its origin in the discovery by Hayashi (1954) of the convulsive effects of l-glutamate and l-aspartate in mammalian brain, and the demonstration later in the decade of the depolarizing and excitatory actions of these amino acids on single central neurones. Today l-glutamate is widely accepted as the predominant excitatory transmitter in the mammalian central nervous system (CNS), acting at a range of different receptor types. The particular role of the N-methyl-d-aspartate (NMDA) type of glutamate receptor in CNS function is highlighted in the book. This chapter reviews the historical aspects of the NMDA receptor concept.

Keywords: NMDA receptor; NDMA; central nervous system; central neurones; mammalian brain

Chapter.  10681 words.  Illustrated.

Subjects: Neuroscience

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