Chapter

Agonists and competitive antagonists: structure-activity and molecular modelling studies

D. E. JANE, H. J. OLVERMAN and J. C. WATKINS

in The NMDA Receptor

Second edition

Published in print February 1995 | ISBN: 9780192625021
Published online March 2012 | e-ISBN: 9780191724701 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780192625021.003.0002
Agonists and competitive antagonists: structure-activity and molecular modelling studies

Show Summary Details

Preview

A wealth of information has now been generated, especially from radioligand binding studies, regarding the structural requirements for agonist and antagonist binding to the glutamate recognition site on the NMDA receptor. In combination with a number of molecular modelling studies this has been used to elucidate the three-dimensional topology of the receptor site and thus provide a basis for a rational design of new pharmacological agents with agonist or antagonist action at these sites. This chapter outlines the required structural features for agonist and antagonist binding. It then discusses the various molecular modelling studies which have recently been carried out.

Keywords: agonists; molecular modelling; NMDA receptor; receptor site; pharmacological agents

Chapter.  22051 words.  Illustrated.

Subjects: Neuroscience

Full text: subscription required

How to subscribe Recommend to my Librarian

Buy this work at Oxford University Press »

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.