Non-competitive antagonists of N-methyl-D-aspartate


in The NMDA Receptor

Second edition

Published in print February 1995 | ISBN: 9780192625021
Published online March 2012 | e-ISBN: 9780191724701 | DOI:
Non-competitive antagonists of N-methyl-D-aspartate

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The ability of d-α-aminoadipate (DAA) and a range of related substances to act as amino acid antagonists has been found to parallel the ability of these substances to displace binding of tritiated ligands from the recognition site of the NMDA receptor. Important exceptions include Mg2+ and HA-966, which do not displace [3H] d-2-amino-5-phosphonovalerate (d-AP5), a competitive-type NMDA receptor antagonist, from rat brain binding sites. Several other groups of compounds joined this ‘non-competitive’ list in the 1980s and 1990s. This chapter concentrates on chemicals acting at sites other than that for NMDA recognition but which nevertheless influence the functions of the NMDA receptor channel complex.

Keywords: NMDA receptor; NMDA; DAA; tritiated ligands

Chapter.  11126 words.  Illustrated.

Subjects: Neuroscience

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