Chapter

The NMDA receptor, its channel, and its modulation by glycine

P. ASCHER and J. W. JOHNSON

in The NMDA Receptor

Second edition

Published in print February 1995 | ISBN: 9780192625021
Published online March 2012 | e-ISBN: 9780191724701 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780192625021.003.0007
The NMDA receptor, its channel, and its modulation by glycine

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Of the glutamate receptors, the N-methyl-d-aspartate (NMDA) one is certainly the most popular choice of research scientists. This popularity is partly due to the recognition that the receptor plays a major role in a surprising variety of physiological processes (from rhythmic discharges to long-term potentiation) as well as in a number of pathological conditions (from epilepsy to neurodegenerative diseases). It is also due to the fact that the NMDA receptor, considered as a pharmacological target, can be modulated at a number of sites other than the glutamate recognition site. Among these sites, two major ones are the ionic channel itself and an ‘allosteric’ site through which glycine modulates the NMDA response.

Keywords: glutamate receptors; modulation; glycine; NMDA receptors; ionic channels; pharmacological targets

Chapter.  12304 words.  Illustrated.

Subjects: Neuroscience

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