Chapter

The importance of NMDA receptors in the processing of spinal primary afferent input

R. H. EVANS

in The NMDA Receptor

Second edition

Published in print February 1995 | ISBN: 9780192625021
Published online March 2012 | e-ISBN: 9780191724701 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780192625021.003.0011
The importance of NMDA receptors in the processing of spinal primary afferent input

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This chapter covers the following aspects which are relevant to the role of N-methyl-d-aspartate (NMDA) receptors in spinal neurotransmission: the involvement of NMDA receptors and the co-agonist glycine site in long duration spinal reflexes elicited from dorsal roots; the relationship between glutamatergic and peptidergic transmission from primary afferent C fibres; and the selective depression of NMDA-receptive excitatory pathways by analgesic and myorelaxant drugs. It has been reported that long duration synaptic potentials in spinal preparations are a property of early development because in rats older than ten days, synaptic potentials are of much shorter duration than in younger rats. However, such comparisons between spinal root recordings from animals of different ages should be cautiously interpreted.

Keywords: NMDA receptors; spinal neurotransmission; glycine; spinal reflexes; primary afferent C fibres; synaptic potentials

Chapter.  3682 words.  Illustrated.

Subjects: Neuroscience

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