Chapter

NMDA receptors and long-term potentiation in the hippocampus

ZAFAR I. BASHIR, NICOLA BERRETTA, ZUNER A. BORTOLOTTO, KATH CLARK, CERI H. DAVIES, BRUNO G. FRENGUELLI, JENNI HARVEY, BRIGITTE POTIER and GRAHAM L. COLLINGRIDGE

in The NMDA Receptor

Second edition

Published in print February 1995 | ISBN: 9780192625021
Published online March 2012 | e-ISBN: 9780191724701 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780192625021.003.0013
NMDA receptors and long-term potentiation in the hippocampus

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N-methyl-d-aspartate (NMDA) receptors have been shown to have two important physiological roles in the vertebrate central nervous system; they are mediators of synaptic transmission in many pathways in the brain and they are critically involved in neuronal plasticity. This chapter considers long-term potentiation (LTP) in the hippocampus, the first identified and most extensively investigated form of plasticity involving NMDA receptors. The involvement of NMDA receptors in synaptic transmission in the hippocampus is also considered in detail in view of the inextricable link between synaptic transmission and plasticity that NMDA receptors confer upon a synapse.

Keywords: LTP; NMDA receptors; synaptic transmission; hippocampus; central nervous system; neuronal plasticity

Chapter.  6182 words.  Illustrated.

Subjects: Neuroscience

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