Chapter

The role of NMDA receptors in learning and memory

R. G. M. MORRIS and M. DAVIS

in The NMDA Receptor

Second edition

Published in print February 1995 | ISBN: 9780192625021
Published online March 2012 | e-ISBN: 9780191724701 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780192625021.003.0015
The role of NMDA receptors in learning and memory

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An early finding was that AP5 appeared to impair spatial learning, a type of learning known to be dependent upon the integrity of the very structure, the hippocampus, in which LTP was first discovered and is usually investigated. Over the past decade, there has been a greater understanding of the biophysics, neuropharmacology, and molecular biology of NMDA receptors. Knowledge about their role in several kinds of learning and memory has also advanced over this time, and this chapter aims to illustrate three principal aspects of how research in this field has developed.

Keywords: NMDA receptors; learning; memory; neuropharmacology; hippocampus; LTP; AP5; spatial learning

Chapter.  14409 words.  Illustrated.

Subjects: Neuroscience

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