Chapter

Clinical implications of NMDA receptors

PAUL L. HERRLING

in The NMDA Receptor

Second edition

Published in print February 1995 | ISBN: 9780192625021
Published online March 2012 | e-ISBN: 9780191724701 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780192625021.003.0016
Clinical implications of NMDA receptors

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Studies on the physiology and pharmacology of excitatory amino acids led to a new understanding of the high degree of complexity of excitatory transmission in the brain, far removed from the early concept that post-synaptic depolarization caused excitation and hyperpolarization inhibition. As a consequence of this recent knowledge, workers in the field have proposed therapeutic applications for drugs modulating excitatory amino acid systems, ranging across the entire field of psychiatry and neurology, although only a very limited number of such compounds have reached the stage of clinical evaluation. This chapter attempts to summarize the proposed therapeutic applications for drugs modulating excitatory amino acids and provides a short description of the rationale which led to these proposals. The emphasis is on NMDA-modulating compounds, but there is also mention of possible clinical applications for compounds acting at non-NMDA receptors.

Keywords: NMDA receptors; excitatory amino acids; depolarization; hyperpolarization; therapeutic applications; psychiatry; neurology

Chapter.  8045 words. 

Subjects: Neuroscience

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