Chapter

Competitive NMDA antagonists as drugs

B. S. MELDRUM and A. G. CHAPMAN

in The NMDA Receptor

Second edition

Published in print February 1995 | ISBN: 9780192625021
Published online March 2012 | e-ISBN: 9780191724701 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780192625021.003.0019
Competitive NMDA antagonists as drugs

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The potential clinical applications of N-methyl-d-aspartate (NMDA) antagonists were initially defined on the basis of animal models. Epilepsy was the first target syndrome identified and remains an important potential therapeutic area. Today stroke and traumatic injury of the spinal cord and brain are the most important clinical targets. The possibility of using NMDA antagonists as long-term therapies in chronic neurodegenerative disorders seems relatively remote, largely because of the problem of side effects. This chapter lists potential therapeutic targets for NMDA antagonists. Before reviewing preclinical and clinical data relating to the therapeutic prospects of NMDA antagonists this chapter briefly reviews currently available compounds.

Keywords: NMDA antagonists; animal models; epilepsy; spinal cord injury; neurodegenerative disorders; therapeutic targets

Chapter.  4332 words.  Illustrated.

Subjects: Neuroscience

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