11. Gene–nutrient interactions in nutritional epidemiology

Lenore Kohlmeier, David DeMarini and Walter Piegorsch

in Design Concepts in Nutritional Epidemiology

Second edition

Published in print April 1997 | ISBN: 9780192627391
Published online September 2009 | e-ISBN: 9780191723704 | DOI:
11. Gene–nutrient interactions in nutritional epidemiology

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There is increasing evidence that the ways in which nutrients are handled metabolically is, to a greater or lesser extent, under genetic control. Equally, nutrient (and non-nutrient) intakes affect the expression of genetic predispositions. These complex interactions (nutrient regulation of gene transcription, food-induced DNA damage, phytochemical enhancement or protection of DNA integrity, genetic susceptibility to nutrition-related diseases) increasingly shed light on epidemiological relationships between diet and health and disease. This chapter considers design and analytical implications for understanding gene-nutrient interactions, including specific statistical models. It concludes with a discussion of ethical issues, and an appendix for sample size determination in relation to the determination of genetic characteristics in nutritional epidemiological studies.

Keywords: genetics; gene-nutrient interactions; DNA damage; DNA integrity; sample size; ethics

Chapter.  12265 words.  Illustrated.

Subjects: Public Health and Epidemiology

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