Chapter

Cancer biology

Peter Hoskin and Wendy Makin

in Oncology for Palliative Medicine

Second edition

Published in print August 2003 | ISBN: 9780192628114
Published online November 2011 | e-ISBN: 9780191730115 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780192628114.003.0002
Cancer biology

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Malignant cells differ from normal tissues in a number of fundamental properties. The malignancy in cells is a result of the changes in the genetic make-up of the cells. Changes in the sequences of the DNA due to amplification of protein production are associated with the development and maintenance of malignant growth. Furthermore, changes in cell regulation and tissue growth also lead to malignancy. This chapter focuses on the biological issues of cancer to equip readers with a comprehensive background on the processes by which a malignant growth can cause symptoms from both the local and metastatic sides and by which malignancy can cause death. Discussions in it include the aetiology of cancer, the different stages of carcinogenesis, the high incidence of cancer due to genetic factors and gene abnormality, and the history and progression of malignant disease.

Keywords: malignant cells; malignancy; cells; DNA; cell regulation; tissue growth; biological issues; carcinogenesis; genetic factors; gene abnormality

Chapter.  2950 words.  Illustrated.

Subjects: Palliative Medicine

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