Chapter

Epidemiology and cancer trials

Peter Hoskin and Wendy Makin

in Oncology for Palliative Medicine

Second edition

Published in print August 2003 | ISBN: 9780192628114
Published online November 2011 | e-ISBN: 9780191730115 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780192628114.003.0003
Epidemiology and cancer trials

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This chapter outlines the significant information on the prevalence of cancer in a population, the methods in obtaining clinical information on the disease, and the levels of certainty with which this clinical information can be interpreted. Its emphasis is on epidemiology and cancer trials. Even in palliative care where the endpoint may not be survival rather symptom control, it is necessary that assessment is founded upon sound scientific-based evaluations. This means evaluation of different management methods should be done through clinical trials. The first section of the chapter discusses the distribution of cancer within the population. Discussions include the incidence and prevalence of cancer within a population; the epidemiology of human cancer; and the age, sex, geographic, and ethic variations that determine the prevalence of cancer within a population. The second section discusses the standard staging systems, survival and mortality data, response data, and quality of life assessment. Latter sections focus on the sources of data and clinical trials, health economic assessments, and clinical research.

Keywords: prevalence of cancer; epidemiology; cancer trials; distribution of cancer; standard staging systems; survival data; mortality data; response data

Chapter.  5261 words.  Illustrated.

Subjects: Palliative Medicine

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