Chapter

Colorectal cancer

Peter Hoskin and Wendy Makin

in Oncology for Palliative Medicine

Second edition

Published in print August 2003 | ISBN: 9780192628114
Published online November 2011 | e-ISBN: 9780191730115 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780192628114.003.0008
Colorectal cancer

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This chapter discusses colorectal cancer, which is the second most common malignancy in the United Kingdom. It has an incidence of 30,000 cases annually and is the cause of the deaths of over 20,000 people per year. The risk of developing colorectal cancer increases with age, with sharp probability from the age of 50 onwards. Colorectal cancer, or bowel cancer, develops by a sequence of events, from dysplasia through malignant transformation within the adenomatous polyp. This process is often linked with predisposing genetic factors and exposure to environmental carcinogens. This cancer is predominant in people with familial polyposis coli as well as hereditary non-polyposis colon cancers (HNCC). However, 25 per cent of colorectal cancer and polyposis is attributed to spontaneous genetic mutation and not family history. Other discussions in the chapter are the pathology of bowel cancer, management strategies of early-diagnosed colorectal disease, problems associated with recurrent and late-diagnosed colorectal disease, and palliation of late-diagnosed bowel cancer.

Keywords: colorectal cancer; bowel cancer; dysplasia; adenomatous polyp; polyposis coli; colon cancers; polyposis

Chapter.  4015 words.  Illustrated.

Subjects: Palliative Medicine

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