<i>Neural tube defects</i>

Nicholas Wald

in Antenatal and Neonatal Screening

Second edition

Published in print November 2000 | ISBN: 9780192628268
Published online September 2009 | e-ISBN: 9780191723605 | DOI:
Neural tube defects

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Antenatal screening and diagnosis for neural tube defects involves the application of two methods — maternal serum alphafetoprotein (AFP) followed by amniotic fluid AFP measurement, and ultrasound examination of the fetus. The present challenge in screening is to integrate the two methods into a coherent screening strategy. This chapter quantifies the screening and diagnostic performance of the different methods, and offers a view on how they could be integrated.

Keywords: antenatal screening; antenatal diagnosis; maternal serum alphafetoprotein; amniotic fluid alphafetoprotein; ultrasound; neural trube defects

Chapter.  10040 words.  Illustrated.

Subjects: Public Health and Epidemiology

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