<i>Amniocentesis and chorionic villus sampling</i>

Christine Gosden, Ann Tabor, Ian Leck, Adrian Grant, Zarko Alfirevic and Nicholas Wald

in Antenatal and Neonatal Screening

Second edition

Published in print November 2000 | ISBN: 9780192628268
Published online September 2009 | e-ISBN: 9780191723605 | DOI:
Amniocentesis and chorionic villus sampling

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This chapter reviews amniocentesis and chorionic villus sampling (CVS) to obtain tissue of the same genetic origin as the fetus for diagnostic purposes (most often testing for chromosomal abnormalities) without removing any tissue from the fetus itself. Second-trimester amniocentesis is a very effective test: failure to make a diagnosis is very rare. It involves a small risk of fetal loss, estimated at about 1 in 100 pregnancies. CVS is somewhat less effective, comparably safe if performed transabdominally, but less so if performed transvaginally.

Keywords: antenatal diagnosis; amniocentesis; chorionic villus sampling; chromosomal abnormalities

Chapter.  21112 words.  Illustrated.

Subjects: Public Health and Epidemiology

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