Chapter

Quantitative measurement using fMRI

Richard D. Hoge and G. Bruce Pike

in Functional Magnetic Resonance Imaging

Published in print November 2001 | ISBN: 9780192630711
Published online March 2012 | e-ISBN: 9780191724770 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780192630711.003.0008
Quantitative measurement using fMRI

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Recent developments have permitted the extension of magnetic resonance imaging into the realm of quantitative physiological monitoring. This chapter reviews the various features of the physiological response that can be monitored using functional magnetic resonance imaging (fMRI), and then discusses quantitative models linking physiology and MRI-visible physical parameters. MRI offers several extremely attractive strengths that play an important role in the study of brain physiology as well as clinical practice. The chapter covers the basic physical principles involved in magnetic resonance imaging of cerebral blood flow (CBF), cerebral blood volume (CBV) and cerebral blood oxygenation, and then shows how these measurements can be incorporated into biophysical models that, in conjunction with physiological calibration procedures, can be used to estimate relative changes in the oxygen utilization rate of brain tissue. These techniques can also be used for comparing values of physiological parameters across different brain regions. Finally, the chapter shows that the challenge of measuring dynamic CBV changes while retaining the ability to monitor BOLD signal levels and flow must be overcome, and provides a solution to this problem.

Keywords: quantitative models; physiology; physical parameters; magnetic resonance imaging; signal levels; cerebral blood flow; cerebral blood flow

Chapter.  9097 words.  Illustrated.

Subjects: Neuroscience

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