<i>Champing at the bit</i>

William A. Silverman

in Where's the Evidence?

Published in print April 1999 | ISBN: 9780192630889
Published online September 2009 | e-ISBN: 9780191723568 | DOI:
Champing at the bit

More Like This

Show all results sharing this subject:

  • Public Health and Epidemiology


Show Summary Details


This chapter presents a 1995 commentary on the development of sequential designs for ‘continuous peeking’ in clinical trials, and the use of independent monitoring committees to conduct interim analysis of results. In recent years, such close oversight spawned its own set of problems — increasing pressure on trialists to stop enrolling patients when preliminary trends become apparent, before the study design call for termination of the trials.

Keywords: medical trials; clinical trials; monitoring; study design

Chapter.  1945 words. 

Subjects: Public Health and Epidemiology

Full text: subscription required

How to subscribe Recommend to my Librarian

Buy this work at Oxford University Press »

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.