Chapter

Voltage-gated sodium channels

Misbah Malik-Hall, John N. Wood and Kenji Okuse

in Receptor and Ion-Channel Trafficking

Published in print August 2002 | ISBN: 9780192632241
Published online March 2012 | e-ISBN: 9780191724763 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780192632241.003.0001

Series: Molecular and Cellular Neurobiology Series

Voltage-gated sodium channels

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It is known that the neuron-specific pattern of transcription of some voltage-gated sodium channels (VGSCs) is regulated by a specific sequence, the NRSE/RE1 (neuron-restricted silencing element) and its cognate binding protein. In addition, a role for accessory subunits in high-level channel expression and channel anchoring with respect to extracellular signals is also now established. More recently, signals ranging from growth factors such as GDNF to nerve damage or demyelinating diseases have been shown to alter the cohort of sodium (Na) channels expressed in neurons and may also alter their spatial pattern of expression. This chapter focuses on the possible regulatory role of accessory subunits that have been found to associate with Na channel α subunits, and factors that alter channel expression.

Keywords: VGSCs; demyelinating diseases; extracellular signals; nerve damage; sodium channels; neurons; channel expression

Chapter.  12623 words.  Illustrated.

Subjects: Neuroscience

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