Voltage-gated sodium channels

Misbah Malik-Hall, John N. Wood and Kenji Okuse

in Receptor and Ion-Channel Trafficking

Published in print August 2002 | ISBN: 9780192632241
Published online March 2012 | e-ISBN: 9780191724763 | DOI:

Series: Molecular and Cellular Neurobiology Series

Voltage-gated sodium channels

Show Summary Details


It is known that the neuron-specific pattern of transcription of some voltage-gated sodium channels (VGSCs) is regulated by a specific sequence, the NRSE/RE1 (neuron-restricted silencing element) and its cognate binding protein. In addition, a role for accessory subunits in high-level channel expression and channel anchoring with respect to extracellular signals is also now established. More recently, signals ranging from growth factors such as GDNF to nerve damage or demyelinating diseases have been shown to alter the cohort of sodium (Na) channels expressed in neurons and may also alter their spatial pattern of expression. This chapter focuses on the possible regulatory role of accessory subunits that have been found to associate with Na channel α subunits, and factors that alter channel expression.

Keywords: VGSCs; demyelinating diseases; extracellular signals; nerve damage; sodium channels; neurons; channel expression

Chapter.  12623 words.  Illustrated.

Subjects: Neuroscience

Full text: subscription required

How to subscribe Recommend to my Librarian

Buy this work at Oxford University Press »

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.