Chapter

Targeting of acetylcholine receptors to the postsynaptic endplate of the nerve–muscle synapse

Sheridan L. Swope

in Receptor and Ion-Channel Trafficking

Published in print August 2002 | ISBN: 9780192632241
Published online March 2012 | e-ISBN: 9780191724763 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780192632241.003.0004

Series: Molecular and Cellular Neurobiology Series

Targeting of acetylcholine receptors to the postsynaptic endplate of the nerve–muscle synapse

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Synaptic transmission is dependent on the precise juxtaposition of the presynaptic nerve terminal with a localized high density of neurotransmitter receptors in the postsynaptic cell. For decades, the neuromuscular junction (NMJ) has served as an excellent system to study the molecular biology, biochemistry, and cell biology of synapse formation and function. The enrichment of synaptic components in the electric organs of Torpedo californica (TEO) has provided a system to identify, purify, clone, and characterize the function of the molecular components at the NMJ. The nicotinic acetylcholine receptor (nAChR) is the ligand-gated ion channel that mediates rapid depolarization of the postsynaptic membrane at the NMJ.

Keywords: presynaptic nerve terminal; synaptic transmission; acetylcholine receptors; neuromuscular junction; Torpedo californica

Chapter.  10685 words.  Illustrated.

Subjects: Neuroscience

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