Chapter

Ampa/kainate receptors

Nicole L. Stricker and Richard L. Huganir

in Receptor and Ion-Channel Trafficking

Published in print August 2002 | ISBN: 9780192632241
Published online March 2012 | e-ISBN: 9780191724763 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780192632241.003.0006

Series: Molecular and Cellular Neurobiology Series

Ampa/kainate receptors

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The three major types of ionotropic glutamate receptors are the N-methyl-d-aspartate (NMDAR), α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPAR), and kainate (KAR) receptors. AM PARs and KARs mediate fast excitatory transmission, whereas NMDARs mediate a slower component of synaptic transmission which is important for modulation of synaptic and neuronal function. This chapter focuses on the mechanisms of AMPA and kainate glutamate receptor assembly, synaptic localization, and surface expression.

Keywords: ionotropic glutamate receptors; NMDAR; AMPAR; kainate glutamate receptors; synaptic localization; surface expression; neuronal function

Chapter.  12892 words.  Illustrated.

Subjects: Neuroscience

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