Chapter

NMDA receptor targeting

Heike Hering and Morgan Sheng

in Receptor and Ion-Channel Trafficking

Published in print August 2002 | ISBN: 9780192632241
Published online March 2012 | e-ISBN: 9780191724763 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780192632241.003.0007

Series: Molecular and Cellular Neurobiology Series

NMDA receptor targeting

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The N-methyl-d-aspartate (NMDA) class of ionotropic glutamate receptor has received special attention because it is critical for many forms of activity-dependent synaptic plasticity, some of which may underlie learning and memory in the brain. For instance, the blockade of NMDA receptors prevents long-term potention (LTP) in the hippocampus and impairs learning. NMDA receptor stimulation allows an influx of calcium ions into the postsynaptic cell and the activation of multiple intracellular signaling pathways. The signal transduction events initiated by NMDA receptor stimulation involve protein kinases, phosphatases, small GTPases and other enzymes, leading to changes in the cytoskeleton, membrane excitability, cell adhesion, transcription, and translation and other adaptive responses in the postsynaptic cell.

Keywords: NMDA receptor; protein kinases; protein phosphatases; GTPases; synaptic plasticity; learning; memory; LTP; postsynaptic cell; intracellular signaling pathways

Chapter.  7203 words.  Illustrated.

Subjects: Neuroscience

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