Structure, assembly and targeting of glycine receptors

Kirsten Harvey, Jeska von der Nuell and Robert J. Harvey

in Receptor and Ion-Channel Trafficking

Published in print August 2002 | ISBN: 9780192632241
Published online March 2012 | e-ISBN: 9780191724763 | DOI:

Series: Molecular and Cellular Neurobiology Series

Structure, assembly and targeting of glycine receptors

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Glycine receptors (GlyRs) are widely known to be responsible for the control of motor and sensory pathways in the spinal cord and brain stem, and are a major target for modulation by alcohol, volatile general anaesthetics, and inhaled drugs of abuse. Several developmentally and regionally regulated GlyR isoforms exist, which result from the differential expression of five genes coding for ligand-binding GlyR α (α1–α4) and structural β subunits. Additional GlyR subunit diversity arises from alternative splicing of the α1, α2, α3, and β subunit transcripts. Sequence comparisons have shown that the GlyR is part of a ligand-gated ion channel superfamily which includes nicotinic acetylcholine receptors (nAChRs), γ-aminobutyric acid type A (GABAA) and C (GABAC) receptors, serotonin type 3 (5HT3) receptors and glutamate-gated chloride channels from invertebrates.

Keywords: glycine receptors; motor pathways; sensory pathways; spinal cord; GlyR isoforms; gene coding; transcripts

Chapter.  11004 words.  Illustrated.

Subjects: Neuroscience

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