Chapter

Active Behavior of the Membrane

Jaakko Malmivuo

in Bioelectromagnetism

Published in print October 1995 | ISBN: 9780195058239
Published online March 2012 | e-ISBN: 9780199847839 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780195058239.003.0004
Active Behavior of the Membrane

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This chapter describes the voltage clamp device, the experiments of Hodgkin and Huxley, the mathematical model into which their data were fitted, and the resulting simulation of a wide variety of recognized electrophysiological phenomena (activation, propagation, etc.). The voltage clamp procedure was developed in 1949. Because of its importance, this chapter first discusses the principle of the voltage clamp method in detail. The Hodgkin and Huxley work is important not only for its ability to describe quantitatively both the active and the passive membrane, but for its contribution to a deeper understanding of the membrane mechanisms that underlie its electrophysiological behavior.

Keywords: electrophysiology; Hodgkin and Huxley experiments; voltage clamp; active membrane; passive membrane; stimulation

Chapter.  16377 words.  Illustrated.

Subjects: Neuroscience

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