Chapter

Bidomain Model of Multicellular Volume Conductors

Jaakko Malmivuo

in Bioelectromagnetism

Published in print October 1995 | ISBN: 9780195058239
Published online March 2012 | e-ISBN: 9780199847839 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780195058239.003.0009
Bidomain Model of Multicellular Volume Conductors

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Many investigations in electrophysiology involve preparations that contain multiple cells. Examples include the nerve bundle, which consists of several thousand myelinated fibers; striated whole muscle, which may contain several thousand individual fibers; the heart, which has on the order of 1010 cells; and the brain, which also has about 1010 cells. In modeling the electric behavior of such preparations, the discrete cellular structure may be important. On the other hand, macroscopic (averaged) fields may adequately describe the phenomena of interest. In the latter case it is possible to replace the discrete structure with an averaged continuum that represents a considerable simplification. This chapter aims to formulate a continuum representation of multicellular systems and then to explore its electric properties.

Keywords: volume conductor; multicellular systems; electric behavior; bidomain model; electrophysiology; striated muscle

Chapter.  4781 words.  Illustrated.

Subjects: Neuroscience

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