Chapter

Applications of the Case-Control Study

Ezra Susser, Sharon Schwartz, Alfredo Morabia and Evelyn J. Bromet

in Psychiatric Epidemiology

Published in print July 2006 | ISBN: 9780195101812
Published online September 2009 | e-ISBN: 9780199864096 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780195101812.003.16

Series: Oxford Psychiatry Series

Applications of the Case-Control Study

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Implementing a case-control study presents three central challenges. The first is to select cases and controls from the same source population. The investigator attempts to visualize the population that gave rise to the cases, and to select the controls appropriately from this population. The second is to establish the temporal order of exposure and disease. As opposed to the cohort study, in the case-control study the antecedence of the exposure to the disease is not established by design. The third is to obtain an unbiased measure of the exposure with information retrieved retrospectively, after the outcome is already known. The retrospective measurement presents the problem that misclassification of the exposure can be linked to the disease status. This chapter illustrates how case-control studies of psychiatric disorders have attempted to meet these challenges.

Keywords: case-control studies; temporal order; differential misclassification; population; exposure; unbiased measure

Chapter.  5081 words.  Illustrated.

Subjects: Public Health and Epidemiology ; Medical Statistics and Methodology

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