Choosing Cases in Biologic Psychiatry

Ezra Susser, Sharon Schwartz, Alfredo Morabia and Evelyn J. Bromet

in Psychiatric Epidemiology

Published in print July 2006 | ISBN: 9780195101812
Published online September 2009 | e-ISBN: 9780199864096 | DOI:

Series: Oxford Psychiatry Series

Choosing Cases in Biologic Psychiatry

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  • Public Health and Epidemiology
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The previous chapter proposed that biologic studies comparing cases with controls often correspond well to the case-control design. This chapter shows how this perspective can be useful for advancing biological psychiatry, focusing on the selection and the definition of cases in biologic studies. It argues that in biological studies comparing cases and controls, the principles developed by epidemiologists for the selection of cases in ordinary case-control studies can often be put in practice and substantially strengthen the design. However, these practices would impose unnecessary constraints on some biological studies in psychiatry, and their application must always be tailored to yield a net advantage.

Keywords: biologic studies; case-control studies; study design; case selection; biological psychiatry

Chapter.  4755 words.  Illustrated.

Subjects: Public Health and Epidemiology ; Medical Statistics and Methodology

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