Chapter

Genetic Linkage Studies

Ezra Susser, Sharon Schwartz, Alfredo Morabia and Evelyn J. Bromet

in Psychiatric Epidemiology

Published in print July 2006 | ISBN: 9780195101812
Published online September 2009 | e-ISBN: 9780199864096 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780195101812.003.32

Series: Oxford Psychiatry Series

Genetic Linkage Studies

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This chapter describes the basic concepts and methods of genetic linkage studies. It first describes what linkage means and how investigators go about detecting linkage. It then discusses the causal paradigm of the genetic linkage study and contrasts linkage with association studies. Finally, using the example of dystonia, it shows how linkage can be interwoven with other designs in the search for genetic causes.

Keywords: genetic linkage study; association studies; dystonia; genetic causes

Chapter.  5628 words.  Illustrated.

Subjects: Public Health and Epidemiology

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