Chapter

Clinical Significance

Jeremy D. Schmahmann and Deepak N. Pandya

in Fiber Pathways of the Brain

Published in print April 2006 | ISBN: 9780195104233
Published online May 2009 | e-ISBN: 9780199864294 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780195104233.003.0028
 Clinical Significance

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This chapter draws upon the cases of selected individual patients, mostly from personal clinical experience, to focus on the apparent wider clinical relevance of white matter anatomy and disorders. It discusses diseases of the white matter that cause dementia, selected examples of focal white matter lesions that produce cognitive and sensorimotor manifestations, and the phenomena of white matter attrition and pruning. Finally, it addresses the question of the effect of lesion location on recovery from neurological deficit.

Keywords: white matter; brain; dementia; white matter attrition; pruning; lesions

Chapter.  9314 words.  Illustrated.

Subjects: Neuroscience

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