Chapter

The Satiating Effects of Cholecystokinin and Bombesin-Like Peptides

GERARD P. SMITH and JAMES GIBBS

in Satiation: From Gut to Brain

Published in print January 1998 | ISBN: 9780195105155
Published online March 2012 | e-ISBN: 9780199848263 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780195105155.003.0005
The Satiating Effects of Cholecystokinin and Bombesin-Like Peptides

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This chapter reviews cholecystokinin and the bombesin-like peptides gastrin-releasing peptide and neuromedin B. The chapter discusses in detail the work with cholecystokinin that led to its identification as the first molecule to have a satiating effect under physiological conditions because it provided the experimental framework in which other peptides have been investigated and the criteria by which their physiological function has been judged. The chapter presents a case study of how a satiating effect of an endogenous peptide can be distinguished from nonspecific or toxic effects.

Keywords: cholecystokinin; neuromedin B; toxicity; endogenous peptides

Chapter.  11710 words.  Illustrated.

Subjects: Neuroscience

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