Chapter

Measurement and Classification of Exposure

David A. Savitz

in Interpreting Epidemiologic Evidence

Published in print July 2003 | ISBN: 9780195108408
Published online September 2009 | e-ISBN: 9780199865765 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780195108408.003.0008
Measurement and Classification of Exposure

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Exposure becomes a legitimate target of epidemiologic inquiry once it has been clearly linked to disease, e.g., tobacco or asbestos. Exposure includes exogenous agents such as drugs, diet, and pollutants, as well as genetic attributes that affect ability to metabolize specific compounds; stable attributes such as height or hair color; physiologic characteristics such as blood pressure; behaviors such as physical exercise; mental states such as stress or depression; the social environment, including poverty and discrimination; and participation in health care, such as disease screening and receipt of immunizations. This chapter discusses ideal versus operational measures of exposure, the evaluation of exposure misclassification, assessment of whether exposure misclassification is differential or nondifferential, and integrated assessment of potential for bias due to exposure misclassification.

Keywords: epidemiological research; epidemiological studies; exposure misclassification; integrated assessment

Chapter.  18359 words.  Illustrated.

Subjects: Public Health and Epidemiology

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