Book

Molecular and Cellular Approaches to Neural Development

Edited by W. Maxwell Cowan, Thomas M. Jessell and S. Lawrence Zipursky

Published in print April 1998 | ISBN: 9780195111668
Published online May 2009 | e-ISBN: 9780199865833 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780195111668.001.0001

Series: Adolescent Mental Health Initiative

Molecular and Cellular Approaches to Neural Development

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Although the major features of neural development have been known for nearly a century, it is only relatively recently that the underlying molecular and cellular mechanisms have begun to be uncovered. Among the many factors accountable for the transformation of developmental neurobiology from a largely descriptive to an analytic and mechanistic discipline, two stand out as singularly important. First has been the application of molecular genetic methods to the study of such events and neural induction, the determination of neuronal phenotypes, the establishment of neuronal processes, and the formation of specific patterns of connections. The second factor has been the use of a variety of “model” organisms: each offering particular advantages in the study of one or another developmental process. The pace of new advances often overwhelms experienced workers in the field. This book updates and introduces the subject and also details recent successes in understanding the early events of neural development.

Keywords: neural development; molecular mechanisms; cellular mechanisms; molecular genetic methods; neural induction; neuronal phenotypes; neuronal processes; model organisms

Book.  574 pages.  Illustrated.

Subjects: Neuroscience

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Table of Contents

Neural induction in <i>Xenopus</i> in Molecular and Cellular Approaches to Neural Development

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The determination of the neuronal phenotype in Molecular and Cellular Approaches to Neural Development

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Neuron–glial interactions in Molecular and Cellular Approaches to Neural Development

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Molecular mechanisms of axon guidance and target recognition in Molecular and Cellular Approaches to Neural Development

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Synapse formation: a molecular perspective in Molecular and Cellular Approaches to Neural Development

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Neurotrophic factors and their receptors in Molecular and Cellular Approaches to Neural Development

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Neuronal cell death in Molecular and Cellular Approaches to Neural Development

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Inductive signals and the assignment of cell fate in the spinal cord and hindbrain in Molecular and Cellular Approaches to Neural Development

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The role of <i>Hox</i> genes in hindbrain development in Molecular and Cellular Approaches to Neural Development

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Regulation of patterning and differentiation in the embryonic vertebrate forebrain in Molecular and Cellular Approaches to Neural Development

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