Chapter

Neural induction in <i>Xenopus</i>

Richard M. Harland

in Molecular and Cellular Approaches to Neural Development

Published in print April 1998 | ISBN: 9780195111668
Published online May 2009 | e-ISBN: 9780199865833 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780195111668.003.0001
 Neural induction in Xenopus

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This chapter discusses the biology of neural induction in Xenopus laevis. Recently, several diverse mechanisms that have been proposed to account for neural induction have been simplified into one. Evidence supporting the proposed mechanism—which hinges on the function of the bone morphogenetic protein family (BMP)—is reviewed. Signalling by BMPs biases ectoderm toward an epidermal fate. BMP mRNAs are presented in the ectoderm, and blockage of their function by cell dissociation, use of dominant negative BMP receptors, or dominant negative BMP ligands results in neural development.

Keywords: Xenopus laevis; bone morphogenetic protein; neural induction; ectoderm; cell dissociation

Chapter.  12123 words.  Illustrated.

Subjects: Neuroscience

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