Chapter

Inductive signals and the assignment of cell fate in the spinal cord and hindbrain

Thomas M. Jessell and Andrew Lumsden

in Molecular and Cellular Approaches to Neural Development

Published in print April 1998 | ISBN: 9780195111668
Published online May 2009 | e-ISBN: 9780199865833 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780195111668.003.0008
 Inductive signals and the assignment of cell fate in the spinal cord and hindbrain

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Recent studies of the molecular mechanisms that control the identity and pattern of neural cell types generated in vertebrate embryos have focused on three main issues: (i) defining the source and identity of signals controlling the fate of nearby cells; (ii) defining cell-intrinsic factors that commit neural cells to specific fates; and (iii) determining how intrinsic regulatory proteins direct the expression of the sensory machinery required in and on the growth cone for recognition of local guidance cues. This chapter focuses on the patterning mechanisms implicated in the generation of distinct cell types at caudal levels of the neural tubes that give rise to the segmentally organized structure of the spinal cord and hind brain.

Keywords: spinal cord; hindbrain; neural cell types; molecular mechanisms; neural tubes

Chapter.  20807 words.  Illustrated.

Subjects: Neuroscience

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