Chapter

The role of <i>Hox</i> genes in hindbrain development

Mario R. Capecchi

in Molecular and Cellular Approaches to Neural Development

Published in print April 1998 | ISBN: 9780195111668
Published online May 2009 | e-ISBN: 9780199865833 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780195111668.003.0009
 The role of Hox genes in hindbrain development

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This chapter discusses current understanding of hindbrain development with particular emphasis on the roles of Hox genes in mediating this process. The chapter is divided into three sections. The first section explores the properties of rhombomeres that influence how the neuronal architecture of the hindbrain is formed. The second examines the organization, expression patterns, and genetic function of Hox genes. The positional cues for patterning the head and neck appear to depend on the underlying embryonic organization of the central nervous system. The third section focuses on the neural crest, which is the conduit for transferring this positional information.

Keywords: rhombomeres; Hox genes; neural crest; brain development; hindbrain

Chapter.  10557 words.  Illustrated.

Subjects: Neuroscience

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