Chapter

Regulation of patterning and differentiation in the embryonic vertebrate forebrain

John L. R. Rubenstein and Kenji Shimamura

in Molecular and Cellular Approaches to Neural Development

Published in print April 1998 | ISBN: 9780195111668
Published online May 2009 | e-ISBN: 9780199865833 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780195111668.003.0010
 Regulation of patterning and differentiation in the embryonic vertebrate forebrain

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This chapter reviews studies that address the topological arrangement of the histogenic primordial within the forebrain at the neural plate and embryonic neural tube stages. It discusses a neuromeric (segmentation) model which proposes that dorsoventral (D/V) and anteroposterior (A/P) patterning mechanisms subdivide the embryonic forebrain into longitudinal and transverse domains. It describes studies that define the patterning mechanisms that regulate expression of genes whose function is linked to the development of specific histogenic anlage. Finally, the chapter describes genetic studies that define the function of several classes of transcription factors in regulating forebrain patterning, morphogenesis, and differentiation.

Keywords: histogenic primordia; forebrain; neural plate; dorsoventral patterning; anteroposterior patterning; longitudinal domain; transverse domain

Chapter.  16531 words.  Illustrated.

Subjects: Neuroscience

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