Chapter

Lineage analysis in the vertebrate central nervous system

Constance L. Cepko, Jeffrey A. Golden, Francis G. Szele and John C. Lin

in Molecular and Cellular Approaches to Neural Development

Published in print April 1998 | ISBN: 9780195111668
Published online May 2009 | e-ISBN: 9780199865833 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780195111668.003.0011
 Lineage analysis in the vertebrate central nervous system

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This chapter focuses on lineage analysis in the vertebrate nervous system. It begins with the definition of lineal analysis followed by a discussion of methods of lineage analysis. It then presents examples of lineage analysis conducted in the vertebrate central nervous system (CNS). Lineage analysis of the retina has shown that retinal progenitors are multipotent, most likely through the final cell division; the pattern of cell divisions can be symmetric or asymmetric with respect to the mitotic behavior of daughter cells; and postmitotic retinal cells migrate radially with relatively little tangential migration.

Keywords: lineage analysis; clones; retinal analysis; multipotent; symmetric; asymmetric

Chapter.  23709 words.  Illustrated.

Subjects: Neuroscience

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