Neuroendocrine Regulation of Fear and Anxiety

Jay Schulkin and Jeffrey B. Rosen

in Extreme Fear, Shyness, and Social Phobia

Published in print October 1999 | ISBN: 9780195118872
Published online March 2012 | e-ISBN: 9780199848232 | DOI:

Series: Series in Affective Science

Neuroendocrine Regulation of Fear and Anxiety

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This chapter offers an animal model of behavioral inhibition in rats that highlight the role of corticosteroids in the development of fear. It specifically explores the neurodevelopment of behavioral inhibition with emphasis on the body of work derived from the studies on the laboratory rat and rhesus monkey. In these studies, the behavioral inhibition response that is depicted is similar to an emotional predisposition. That is, the behavioral inhibition or freezing response represents the individual's characteristic or developmental reaction to threat. In general, the data of studies discussed show that the responsiveness of the behavioral inhibition system may be modified by early environmental events.

Keywords: behavioral inhibition; animal model; corticosteroid; fear; rat; rhesus monkey; freezing response

Chapter.  14647 words.  Illustrated.

Subjects: Clinical Psychology

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