Chapter

The Mark of Madness

R. Walter Heinrichs

in In Search of Madness

Published in print May 2001 | ISBN: 9780195122190
Published online May 2009 | e-ISBN: 9780199865482 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780195122190.003.0003
 The Mark of Madness

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This chapter focuses on the “markers” of schizophrenia. It evaluates six well-researched potential markers—three cognitive-behavioral (digit span, Continuous Performance Test, visual backward masking) and three cognitive-physiological tasks (smooth pursuit eye movements, P300, P50 evoked potentials) in terms of their ability to identify patients with schizophrenia. Of these six marker candidates, all but the P50 evoked potential abnormality fare equivocally or even badly at the first hurdle. The P50 abnormality, which seems to reflect an inability to filter, dampen, or habituate to sensory experience, has the largest average effect size of the candidate markers and therefore probably has the highest prevalence, in schizophrenia of all candidate markers.

Keywords: schizophrenia; disease markers; genes; specificity; P300; P50

Chapter.  14185 words.  Illustrated.

Subjects: Neuroscience

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