Folic Acid and Neural Tube Defects

Walter Willett

in Nutritional Epidemiology

Second edition

Published in print July 1998 | ISBN: 9780195122978
Published online September 2009 | e-ISBN: 9780199864249 | DOI:

Series: Monographs in Epidemiology and Biostatistics

Folic Acid and Neural Tube Defects

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This chapter reviews studies on the link between folic acid and neural tube defects. These include clinical observations and early interventions, case-control and cohort studies of folic acid intake, case-control and cohort studies of folic acid blood levels, randomized trials, and studies of genetic markers and metabolic indicators. Policy implications and broader implications for nutritional epidemiology are considered.

Keywords: folic acid; neural tube defects; genetic markers; randomized trials; metabolic indicators

Chapter.  9142 words.  Illustrated.

Subjects: Public Health and Epidemiology

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