Chapter

Applying genetic strategies to prevent atherosclerosis

Roger R. Williams, Paul N. Hopkins, Lily L. Wu and Steven C. Hunt

in Genetics and Public Health in the 21st Century

Published in print September 2000 | ISBN: 9780195128307
Published online September 2009 | e-ISBN: 9780199864485 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780195128307.003.0024

Series: Oxford Monographs on Medical Genetics

Applying genetic strategies to prevent atherosclerosis

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Atherosclerotic disease of coronary and cerebral arteries accounts for almost half of all deaths in the United States each year. Heart attacks and strokes are often attributable to inherited predisposition, especially when they occur at a relatively early age. Researchers are accumulating information regarding the role of genetics in influencing the risk factors for atherosclerosis in several major categories, including lipids and lipoproteins (LDL HDL and VLDL cholesterol; Lp(a); triglycerides; apo ALAII, and B; apo E genotypes); glucose and insulin metabolism (diabetes, glucose intolerance, and insulin resistance); prothrombotic factors (fibrinogen, plasminogen activator inhibitor-1, factor VII coagulant activity, homocysteine); and hypertension. This chapter discusses the basic approaches for evaluating and addressing heritable factors for atherosclerosis.

Keywords: atherosclerotic disease; heart disease; public health; genetic factors; strokes

Chapter.  7599 words.  Illustrated.

Subjects: Public Health and Epidemiology

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