Cognitive Event-Related Studies

Jay A. Liveson and Dong M. Ma

in Laboratory Reference for Clinical Neurophysiology

Published in print May 1999 | ISBN: 9780195129243
Published online March 2012 | e-ISBN: 9780199847792 | DOI:
Cognitive Event-Related Studies

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P300 potentials are slow waves that depend on stimuli containing information that the subject must process. The types of stimuli are independent of the sensory modality of the stimuli, and have included auditory, visual, and tactile, among others. The function of these potentials is controversial, but it best correlates with evaluation time when unpredictable events have to be discriminated. At present, these studies can be helpful in distinguishing organic dementia (such as in Alzheimer's disease) from the pseudodementia associated with depression. P300 potentials can be used to evaluate drugs. In addition, abnormalities have been found in schizophrenics, alcoholics and their families, and patients with chronic renal failure. A pre-recorded sequence of intermixed tones is presented in two manners. At first, the subject is instructed to ignore the tone (“ignore” condition). Secondly, the subject is instructed to distinguish the tones (“attend” condition). The desired response occurs only in the latter condition.

Keywords: P300 potentials; stimuli; sensory modality; organic dementia; pseudodementia; ignore condition; attend condition

Chapter.  731 words.  Illustrated.

Subjects: Neuroscience

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