Repetitive Nerve Stimulation Studies

Jay A. Liveson and Dong M. Ma

in Laboratory Reference for Clinical Neurophysiology

Published in print May 1999 | ISBN: 9780195129243
Published online March 2012 | e-ISBN: 9780199847792 | DOI:
Repetitive Nerve Stimulation Studies

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The presynaptic region releases acetylcholine from an immediately available primary store and from a secondary store which can be easily mobilized. With each subsequent nerve impulse, the primary, immediately available store becomes progressively depleted. The secondary store starts to replenish the former, but only after a slight lag. Normally, this is not apparent because there is a safety factor: the nerve releases three times the effective acetylcholine dose. This may become apparent as impulses fail to discharge the muscle fibers effectively (blocking), causing a decrease in the motor response. At the optimal frequency (three hertz) for repetitive nerve stimulation, the primary store is maximally depleted while the secondary store mobilization is minimized. This is the basis of the response to rapid nerve stimulation leading to post-activation potentiation. Several minutes later this is followed by post-activation exhaustion, possibly because of depletion of the presynaptic stores.

Keywords: presynaptic region; acetylcholine; primary store; secondary store; repetitive nerve stimulation; post-activation potentiation; post-activation exhaustion

Chapter.  1948 words.  Illustrated.

Subjects: Neuroscience

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